deus ex computa
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About this program

This program was designed to identify linkage to dominant genes in a single pedigree where there is SNP data for at least one pair of parents (one of whom is affected). Linkage information is then extrapolated from the genotypes of their affected and unaffected children as well as other affected relatives.

Since about 70% to 90% of SNP are not informative the underlying algorthm of DominantMapper requires very high density SNP data like that found in Affymetrix SNP5 and SNP6 datasets. To use these file they must be converted to the old Affymetrix file format which can be done using SNPAnnotator or one of the Illuminator programs.

insilicase icon This program and its instruction file is currently hosted on my department web site and can obtained from here


Carr IM, Johnson CA, Markham AF, Tomes C, Bonthron DT, Sheridan EG.
DominantMapper: Rule-based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families.
Hum Mutat. Accepted 2011 Aug 11

Computer requirements

This program runs on Microsoft Windows, using the .NET 2.0 environment which can be obtained from here.

Copyright © 2011 Insilicase.