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Plink_Assoc_Viewer

About this program

This program allows the output from a PLINK association analysis to be visualised. Each analysis calculates the 'chi-square value (1df'), 'Asymptotic p-value' and 'Estimated odds ratio' results for each SNP. These results are viewed one chromosome at a time by selecting the analysis type from the drop down list in the centre of the window and the chromosome from the drop down list in the lower left corner of the window. The 'chi-square value (1df') and 'Estimated odds ratio' are displayed on a linear axis, while 'Asymptotic p-value' values are shown as the negative Log 10 of the value.

Data for a region can be exported as either a tab delimited text file or a html web page. To export data place the cursor at one side of the region and with the mouse button pressed move the cursor to the other end of the region. Then press the Save button and select the correct file extension and enter the name of the file to save the data too.

Image

Figure 1

The data in a plink.assoc file is arranged as 10 fixed width columns as described in Table 1, the second row states the width of each column, while the third row shows example data. If you analyse the data with the --ci X arguement the file will contain and extra 3 columns, these will be ignored by this program.

Chromosome SNP Position Minor allele Minor allele frequency in affecteds Minor allele frequency in unaffecteds Major allele chi2 value Asymptotic p-value Estimated odds ratio
4 13 11 5 9 9 5 13 13 13
10 RS1530116 122657012 A 0.1083 0.3889 C 22.96 0.000001656 0.1909

insilicase icon Plink_assoc_Viewer can be downloaded from here

Note: this program requires the .NET framework version 2.0 to be installed (available through Windows Update or here).


Plink details
Plink was developed by Shaun Purcell at the Center for Human Genetic Research, Massachusetts General Hospital and has it own web page here
PLINK citation
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. (2007).
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Am J Hum Genet. 81(3):559-75.


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